Utilization of mango ginger (Curcuma mangga Val.) rhizome extracts to decrease serum bilirubin in male rats (Rattus norvegicus L.)

Abstract

This study was conducted to observe the effect of ethanol extract of mango ginger rhizome (Curcuma mangga Val.) on the level of total bilirubin and direct bilirubin liver damage induced by carbon tetrachloride (CCl4). We categorized 24 Sprague-Dawley male rats (Rattusnorvegicus L.) into six treatment groups (NC, TC, T1, T2, T3 and T4). The NC group is a normal control group that was not injected with CCl4 and 0.5 % CMC-fed. The TC group is a treatment control group that was intraperitoneally injected with CCl4 treatment in the amount of 1 ml/kgBW and 0.5 % CMC-fed. T1, T2, T3, and T4 are treatment groups that were injected with CCl4 1 ml/kgBB and were orally administered mango ginger rhizome ethanol extract each at a dose of 10 mg/kgBW, 20 mg/kgBW, 40 mg/kgBW, and 80 mg/kgBW, respectively. The results of Kruskal & Wallis non-parametric test (α = 0.05) shows that the 10 mg/kgBW, 20 mg/kgBW, 40 mg/kgBW and 80 mg/kgBW doses impacted total bilirubin and direct bilirubin levels. Dunnett's (α = 0.05) multiple comparison test result showed that the dosages had no significant differences with KK1 group. In conclusion, the dosages could have curative effects because they successfully reduce the level of total and direct bilirubin until it approached normal level.