Separate isolation of hyperforin from hypericum perforatum (St. John`s Wort) pursuant to the coefficents LOG Kow, PKa and densities of the included compounds

Abstract

It was proven that the most important ingredients of St John's wort-hyperforins and hypericins have a row of physiological activities. On the base of the preliminary observations that hyperforins are stable at slightly alkaline conditions, on the one hand, and when extracted by a highly non-polar solvents a process of their isolation with a high yield was developed. On the other hand, by having in mind the partition coefficients in octanol water, which are very different for hyperforins and hypericins, the two groups of compounds in a pure form for each one were isolated. [ABSTRACT FROM AUTHOR]