Childhood fibroblastic and myofibroblastic tumors: A multicenter documentation and review of the literature

Abstract

Objective: In this study, we aimed to give a documentation of 37 cases of childhood fibroblastic/my fibroblastic tumors retrieved from the archives of 6 reference centers in Ankara along with a comprehensive review on the subject. Material and Method: A retrospective archive search was carried out for the period between 2006-2010 in 6 reference centers in Ankara covering patients with ages ranging between 0-18 years. All the tumors categorized under fibroblastic and my fibroblastic group according to World Health Organization criteria were collected. Results: Te study comprised 407 sof tissue tumors in total. Fibroblastic/my fibroblastic tumors constituted 9,1% (37 cases) of these tumors. According to histopathology; 16 cases were categorized as fibromatosis, 8 cases as inflammatory my fibroblastic tumor, 6 cases as infantile fibrous hamartoma, 3 cases as nodular flasciitis and 2 cases as infantile myofibroblastic tumor/myofibromatosis and 1 case as cranial fasciitis. Te only malignant case was an infantile fibrosarcoma. Conclusion: Infantile fibrosarcoma was lower than reported series and a male predominance was noted. Te low incidence of newly described entities as well suggests that these tumors may have been unrecognized.