Chemerin tips the scales in ccrcc to evade ferroptosis

Abstract

Obesity is both a risk factor for the development of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), and a prognostically protective factor for clinical outcomes. In this issue of Cancer Discovery, Tan and colleagues identify the tumor-and adipose-derived adipokine chemerin as a circulating mediator of ccRCC lipid metabolism and ferroptotic susceptibility that may clarify the paradoxical relationship between ccRCC and obesity.