Development of electrospun wound dressing for hemorrage control using biominerals

Abstract

Study says that haemorrhage in trauma accounts for 30–40% of all fatalities as a cause of death. Wound dressing which can control the blood loss is studied and application of biominerals which is bio compatible got analysed. This field studies on how the mineral particles and textile structures together could be used to design advanced medical products for applications outside human body. From several mineral particles we found one of rock mineral named Montmorillonite is one of mineral particle from soil clay which has high cationic exchange capacity. This controls the haemostasis due to negatively charged particle due to cationic exchange property. These mineral particles are converted into Nano particles and deposited over a nano film and studies are taken. These nano particles delivers high efficient in drug release which leads to faster curing for wound. This nano layer is achieved through textile processed wound dressing electro spinning technology. The proposed system of wound dressing production in electrospinning is by nano film through various combinations and conditions. Due to their nano particle size in electro spun material had advantage on blood clotting is due to superior cationic exchange property while reacting with blood cells results to faster blood clot with reduced pain in healing. Hence the property where studied by comparing nanofilm and coating with powder form and normal dressing. Bio compatibility test is analyzed to compatibility with blood cells of human being through in vitro studies by evaluation by rat cells. Blood clot evaluations are analysed through blood clotting and bleeding time test. In actual bleeding time of normal acute wounds take 240 sec to clot formation hence in our nano film performs clot formation within 40 sec under standard testing conditions.