In vitro activity of ceftolozane-tazobactam and other antimicrobial agents against burkholderia cepacia complex and burkholderia gladioli

Abstract

We tested the activities of ceftolozane-tazobactam and 13 other antimicrobial agents against 221 strains of Burkholderia cepacia complex and Burkholderia gladioli. Most strains (82%) were cultured from persons with cystic fibrosis, and most (85%) were recovered since 2011. The ceftolozane-tazobactam MIC was 8 g/ml for 77% of the strains. However, the MIC range was broad (0.5 to 64 g/ml; MIC50/90, 2/32 g/ml). Significant differences in susceptibility to some antimicrobial agents were observed between species.