Objective: To verify the existence of elements that justify the use of pharmacogenetics by the Brazilian nurse. Method: This is a quantitative, cross-sectional, observational, descriptive study, whose final sample was 67 individuals. The participants were healthy at the time of the study and reported a history of previous use and the occurrence of adverse effects by drugs commonly used and metabolized by CYP2C9. We collected 4 mL of venous blood for subsequent DNA extraction by salting out method and genotyping of the CYP2C9*2 and CYP2C9*3 polymorphisms, using Polymerase Chain Reaction in real time using Taqman assays. Results: The use of drugs metabolized by CYP2C9 was frequent (more than 75% of the individuals have already used between 2 or 4 of these drugs). Regarding adverse events, there were 19 perceived symptomatic occurrences associated with drugs metabolized by CYP2C9. The allele frequency of the polymorphism * 2 and * 3 in the population studied was 11.1% and 7.5%, respectively, and there was a coincidence between the presence of alleles of low enzyme activity and the occurrence of adverse effects. Conclusion: There are elements that justify the adoption of pharmacogenetics in the nursing care to reduce the occurrence of adverse reactions to drugs metabolized by CYP2C9.
CITATION STYLE
De Moraes, J. C., Dornelas Nunes, F. D., Coeli-Lacchini, F. B., Lima Miyazaki, A. H., Floria-Santos, M., & Lacchini, R. (2020). Nurse empowerment through pharmacogenetics. Revista Latino-Americana de Enfermagem, 28, 1–12. https://doi.org/10.1590/1518-8345.3415.3265
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