Capillary electrophoresis to investigate biopharmaceuticals and pharmaceutically-relevant binding properties

Abstract

This review provides an overview of the use of different modes of capillary electrophoresis (CE) for the analysis of biopharmaceuticals and pharmaceuticals from biological fluids. We describe the effective use of CE for assays of the main compound and impurity assessment and for binding assays (Affinity CE). We compare the performance of CE with other frequently used techniques. © 2013 Elsevier Ltd.