Effect of Pearl Millet on Glycaemic Control and Lipid Profile in Streptozocin Induced Diabetic Wistar Rat Model

Abstract

Aims: This study was designed to investigate the effect of Pear millet on glycaemic control and lipid profile in streptozocin diabetic rat model. Methodology: Forty healthy mature male rats were used in this study. The rats divided into 4 groups, ten rats in each and group (A) and (B) normal control rats while group (C) and (D) considered as diabetic rats. Diabetes induced by intraperitoneal injection of 40 mg/kg streptozocin and confirmed by high blood glucose level which considered day 0. The experiment 1, included two groups (A and C), equal rats and the parameters investigated were measured in days 0, 14 and 28. The experiment 2 included two groups (B and D) were received 20% pearl millet and the blood samples were measured in days 0, 14 and 28. Results: The obtained results revealed significant (P<0.05) reduction in insulin and adiponectin (P<0.001) and elevation of blood glucose (P<0.001) in diabetic rats in group C, while significant (P<0.05) reductions in blood glucose, LDL levels and significant (P<0.05) elevation in adiponectin and HDL levels were detected in rats in group B and D.  Conclusions: The studies provide evidence that pearl millet induces hypoglycemic effect and improved lipidemic control in diabetic rats.