Dietary support in hyperhomocysteinemia

Abstract

The study presents a case of a 70-year-old obese male with hyperhomocysteinemia, hypertension, abnormal glucose tolerance, and a history of stroke. Despite medication, his condition persisted due to dietary factors, including excessive salt, protein, and fat intake, and inadequate intake of vitamins B6 and folic acid. The intervention aimed to reduce homocysteine levels, achieve weight loss, improve metabolic health, and optimize nutrient intake. A reduction diet based on DASH and Mediterranean principles was implemented, emphasizing glycemic index/load education and nutrient-balanced meals. After 3 months, significant improvements were observed: weight loss (3.3 kg), reduced body fat percentage, improved body composition, and biochemical enhancements, including decreased homocysteine levels (3.1 μmol/L), increased plasma levels of vitamins B6, B12, and folic acid, and improved lipid profile and glucose levels. These positive outcomes were achieved solely through dietary changes, highlighting the efficacy of tailored dietary interventions in managing complex health conditions without additional pharmacological treatment. The study underscores the importance of personalized dietary strategies in holistic health management, emphasizing the potential for significant health improvements through targeted dietary modifications.