Deep sequencing blood transcriptomes

Abstract

In this issue of Blood, five satellite manuscripts from the Functional Annotation of the Mammalian Genome (FANTOM5) consortium show the power of deep transcriptome sequencing to identify genes, promoters, and enhancers specific to different hematopoietic subpopulations. The papers by Motakis et al and Rönnerblad et al and 2 papers by Schmidl et al examine the transcriptomes of mast cells, 4 cell populations in granulopoiesis, naïve and memory/regulatory and conventional T-cell populations, and CD14/CD16 monocyte subpopulations, respectively, whereas the paper by Prasad et al identifies key cell type specific epigenetic regulators of hematopoiesis. © 2014 by The American Society of Hematology.