Synergy between ketamine and ketogenic diet in anorexia nervosa, and other neurobehavioral disorders

Abstract

Through serendipity, we observed an apparent synergy between adopting a ketogenic diet and receiving ketamine infusions that led to complete and durable remission in two patients with chronic enduring anorexia nervosa. Both patients had struggled with the disorder for over a decade. We offer a hypothesis, based on glutamate to explain this synergy, and hope it stimulates further research.