Risk of acute myocardial infarction or stroke in patients with mycosis fungoides and parapsoriasis

Abstract

Mycosis fungoides (MF) and parapsoriasis display increased inflammation, which may be associated with increased risk of arterial cardiovascular events. The aim of this Danish nationwide population-based cohort study was to assess the relative risk (RR) of acute myocardial infarction (AMI) or stroke in patients with MF and parapsoriasis. In patients with MF, the RR of AMI or stroke was 1.0 (95% confidence interval (95% CI) 0.7–1.3). In the second half of the study period, the RR was 1.8 (95% CI 1.1–2.9) during the first 5 years of follow-up. In men with parapsoriasis, the RR of AMI or stroke was 1.7 (95% CI 1.1–2.7) within the first 5 years of follow-up, whereas the RR of AMI during the first 5 years of followup was 2.0 (95% CI 1.2–3.4). In conclusion, patients with MF and parapsoriasis have an increased RR of AMI or stroke within the first 5 years of follow-up.