NF-κB is a pleiotropic transcription factor with key functions in the intestinal immune system. NF-κB family members control transcriptional activity of various promoters of proinflammatory cytokines, cell surface receptors, transcription factors, and adhesion molecules that are involved in intestinal inflammation. The perpetuated activation of NF-κB in patients with active inflammatory bowel disease suggests that regulation of NF-κB activity is a very attractive target for therapeutic intervention. Such strategies include antioxidants, proteasome inhibitors, inhibition of NF-κB by adenoviral IκBα expression vectors, and antisense DNA targeting of NF- κB. These approaches will hopefully permit the design of new treatment strategies for chronic intestinal inflammation.
CITATION STYLE
Neurath, M. F., Becker, C., & Barbulescu, K. (1998). Role of NF-κB in immune and inflammatory responses in the gut. Gut. BMJ Publishing Group. https://doi.org/10.1136/gut.43.6.856
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