Efficacy of ceftobiprole medocaril against Enterococcus faecalis in a murine urinary tract infection model

Abstract

We evaluated ceftobiprole against the well-characterized Enterococcus faecalis strain OG1RF (with and without the β-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla+ and Bla- OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla+ than Bla- OG1 strains. These data illustrate an in vivo effect on ampicillin of Bla production by E. faecalis and the stability and efficacy of ceftobiprole in experimental UTI. Copyright © 2012, American Society for Microbiology. All Rights Reserved.