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Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Developmental Cell (2020) 53(5) 503-513.e5
DOI: 10.1016/j.devcel.2020.04.012
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Abstract

Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.

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Wei, Q., Nakahara, F., Asada, N., Zhang, D., Gao, X., Xu, C., … Frenette, P. S. (2020). Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. Developmental Cell, 53(5), 503-513.e5. https://doi.org/10.1016/j.devcel.2020.04.012

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