The first application of Selectfluor™ in electrophilic fluorination of amines: A new route to -NF2, -NHF, and > NF compounds

Abstract

Reactions of primary amines, RNH2 [R = (CH3)3C-, (CH3)2CH-, CH3(CH2)2-, (CH3)2CHCH2-, CH3(CH2)3-] and secondary amines, R2NH [(R = CH3CH2-, CH3(CH2)2-, (CH3)2CHCH2-], with Selectfluor™ in acetonitrile or DMF or DMA result in formation of the corresponding RNF2, RNHF, and R2NF in high yields. © 2001 The Royal Society of Chemistry.