The arsonomethyl analogue of 3-phosphoglycerate.

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Abstract

4-Arsono-2-hydroxybutanoic acid, the analogue of 3-phosphoglycerate in which -CH2-AsO3H2 replaces -O-PO3H2, was synthesized. It proved to be a substrate for phosphoglycerate kinase. Its Michaelis constant was only slightly higher than that of the natural substrate, but its catalytic constant was about 1300 times smaller.

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Adams, S. R., Sparkes, M. J., & Dixon, H. B. (1983). The arsonomethyl analogue of 3-phosphoglycerate. The Biochemical Journal, 213(1), 211–215. https://doi.org/10.1042/bj2130211

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