Six end-stage renal disease patients benefited from first non-simultaneous single center 6-way kidney exchange transplantation in India

Abstract

AIM To avoid desensitization protocols and ABO incom-patible kidney transplantation (KT) due to high costs and increased risk of infections from intense immuno-suppression. METHODS We present institutional ethical review board -approved study of single center 6-way kidney exchange transplan-tation. The participants comprised ABO incompatibility (n = 1); positive cross-match and/or presence of donor 532 November 6, 2016|Volume 5|Issue 6| WJN|www.wjgnet.com Kute VK et al . Non-simultaneous single center 6-way kidney exchange in India specific antibody (n = 5). The average time required from registration in kidney paired donation (KPD) regi-stry to find suitable donors was 45 d and time required to perform transplants after legal permission was 2 mo. RESULTS Graft and patient survival were 100%, and 100%, respectively. One patient had biopsy-proven acute borderline T cell rejection (Banff update 2013, type 3). Mean serum creatinine was 0.8 mg/dL at 9 mo follow-up. The waiting time in KPD was short as compared to deceased donor KT. CONCLUSION We report first non-simultaneous, single center, 6-way kidney exchange transplantation from India. Our experi-ence will encourage other centers in India to undertake this practice.