Análisis Farmacocinético y Administración Extravascular; Errores Comunes en el Cálculo y la Interpretación de los Parámetros Farmacocinéticos

Abstract

Pharmacokinetic analysis and extravascular drug administration; com- mon errors in the calculation and interpretation of the kinetic parameters A pharmacokinetic study aims at the knowledgement of the behaviour of a molecule once it has been introduced in the organism. By definition, pharmacokinetics investigates the rate at which the processes of absorption, distribution and elimination take place, and how these processes are expressed mathematically in terms of rate constants. The pharmacokinetic trials performed by intravascular and extravascular administration of any drug are complementary, since the study of the distribution