Antibacterial Activity of Green Synthesized Silver Nanoparticles of Lablab purpureus Flowers Extract against Human Pathogenic Bacteria

Abstract

There are several uses for silver nanoparticles in the field of biomedicine because of their exceptional features. The crucial use of silver nanoparticles is the development of antibiotics that are clinically effective against resistant bacteria. Due to their non-toxicity, environmental friendliness, and faster action, green syntheses of silver nanoparticles have gained some attraction. Plant extracts could be used as efficient sources of reductants and stabilizers in this process and also investigated for antibacterial action. This study mainly aimed to synthesize silver nanoparticles using Lablab purpureus flowers extracts and evaluate the antibacterial properties of the green synthesized sliver nanoparticles. The silver nanoparticles were synthesized and characterized by uv–vis, FT-IR spectroscopy and SEM analysis. Additionally, the disk diffusion method was used to evaluate the antibacterial activity of the silver nanoparticles against one gram positive and five gram negative bacteria. The particle size of synthesized Silver nanoparticles (AgNPs) was less than 1 µm. In bacterial susceptibility study, flower extract of L. purpureus showed moderate antibacterial activity but nanoparticles showed promising antibacterial potential against gram positive S. aureus and gram negative E. coli, moderate antibacterial activity against S. typhi bacteria, and mild activity against P. vulgaris, K. pneumonia and P. aeruginosa. This study indicates that AgNPs made from L. purpureus flower extract exhibit potent antibacterial activity, suggesting these nanoparticles may be used to develop effective anti-bacterial drugs for the treatment of bacterial infections.