The clinical efficiency of lycium-rehmannia pills in treating dry eye symptom: A meta-Analysis

Abstract

Background:Dry eye symptom threatens human health and causes a larger burden of disease, the study aims to systematically compare the therapeutic effect of Lycium-rehmannia pills combined with topical eye drops and pure western medicine (western medicine eye drops) on dry eye symptom, to provide a reflection and enlightenment for clinical treatment.Method:PubMed, The Cochrane Library, EMbase, MEDLINE, CBM, WanFang, VIP, and CNKI databases were searched manually and automatically by the computer until March 2019 and relevant randomized controlled trials (RCTs) were selected. Article selection and data extraction were conducted by 2 researchers independently, then RevMan 5.3 was applied for meta-Analysis.Result:Fifteen randomized controlled trials were included, including 1222 patients (eyes=2382). The meta-Analysis results showed that Lycium-rehmannia pills combined with western medicine were superior to the control group in terms of therapeutic efficiency [OR=4.38, 95% confidence interval (CI) (3.26, 5.89), P