Digestion and Fermentation of Hyaluronic Acid

Abstract

Hyaluronic acid extracted from the crest of chicken was used in the experiment.The quantity of hyaluronic acid was measured by electrophoresis on cellulose acetate. In vitro digestion of hyaluronic acid were measured by artical gastric juice,porcine pancreatin,rats intestinal mucosa and hyaluroniase ovine testes.Enzyme of arttical gastric juice,porcine pancreatin and rats intestinal mucosa digestion of hyaluronic acid were not observed. However,almost complete in vivo digestion and absorption of hyaluronic acid in rats were demonstrated. Microfloral examination revealed an increase in the counts of cecal Lactobacillus and Bzfidobacterirn during the administration of hyaluronic acid.