Sustained Release of Sulfamethizole from Agar Beads after Oral Administration to Humans

Abstract

The use of agar beads for sustained release of a urinary tract disinfectant was examined in vivo. Agar beads containing dispersed sulfamethizole were administered to five healthy volunteers, and the rate of excretion of the drug in urine was determined for pharmacokinetic analysis. The results indicated that agar beads should be useful for the preparation of sustained release dosage forms. © 1980, The Pharmaceutical Society of Japan. All rights reserved.