Esophageal Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma Shared Susceptibility Locus in C20orf54: Evidence from Published Studies

Abstract

This study aimed to determine whether C20orf54 rs13042395 polymorphism modify the risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA) in common population. We conducted a systematic literature review and evaluated the quality of included studies based on Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated to estimate the strengths of the associations. 9 articles (10 studies) were identified for synthesis analyses. Overall, the results indicated that the C20orf54 rs13042395 genotype was subtly decrease the risk of ESCC (T vs. C: ORa €‰=a €‰0.95; 95%CIa €‰=a €‰0.90-0.99; Pa €‰=a €‰0.02) and the rs13042395 polymorphism was associated with a decreased risk of GCA (T vs. C: ORa €‰=a €‰0.95; 95%CIa €‰=a €‰0.91-0.98; Pa €‰