The Preparation of 2, 5-Thiophenedicarboxaldehyde

Abstract

The application of Kröhnke’s method to 2,5-bis(chloromethyl)thiophene has afforded 2,5-thiophenedicarboxaldehyde, from which some condensation products with amines and active methylene compounds have then been derived. 2-Methyl-5-acetyl-3-thiophenecarboxaldehyde and 2-methyl-3,5-thiophenecarboxaldehyde have also been prepared, from 2-methyl-3-chloromethyl-5-acetylthiophene and 2-methyl-3-chloromethyl-5-thiophenecarboxaldehyde respectively, by the Sommelet procedure.