Electrocatalytic behavior and determination of amitriptyline drug with mwcnt@celllulose composite modified glassy carbon electrode

Abstract

A novel nanocomposite of cellulose based on multiwalled carbon nanotube (MWCNT) was synthesized by a simple solution mixing-evaporation method. The morphology, thermal investigations, electrocatalytic oxidation of amitriptylinewere analyzed atmulti-walled carbon/cellulose nanocomposite in detail. The amitriptyline (AMT) drug was electrochemically studied in a phosphate buffer at different pH using the MWCNT/cellulose modified glassy carbon electrode (GCE). As per the linear relationship among AMT along with peak current, differential pulse voltammetry technique has been established for their quantitative pharmaceutical's determination. The oxidation potential shifted negatively compared to GCE, showing that the MWCNT/cellulose modified electrode had an excellent catalytic activity for the AMT oxidation. The anodic peak current varied linear response with AMT's concentration in the range of 0.5 to 20.0 μMwith a LOD of 0.0845 μMand LOQ of 0.282 μM, respectively. The proposedmethod was effectively put on the determination of AMT in pharmaceutical and urine samples. This novelmethodology is presented here as an example of a complete development methodology for the determination of amitriptyline drug and sensor for use in healthcare fields.