Constitutional adaptation of dynamic polymers: Hydrophobically driven sequence selection in dynamic covalent polyacylhydrazones

Abstract

Hydrophobic selection: Reversible polymerization and folding of amphiphilic dialdehyde and dihydrazide monomers yields nanostructured rods. The resulting dynamers are stable enough to resist the incorporation of excess dihydrazide. In water, a more hydrophobic dihydrazide component (see picture, green) is favored over a less hydrophobic one (purple). This selectivity is lost when MeCN is added, implicating that hydrophobicity drives selectivity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.