Thieno[2,3-d]pyrimidine derivatives: Synthetic approaches and their FLT3 kinase inhibition

Abstract

Thienopyrimidines are popular purine bioisosteres, a fundamental piece of the human metabolome. The structural similarity of this scaffold with nucleobases in the nucleic acid of DNA made it an interesting moiety to be used in the design of kinase inhibitors. This review focuses on the chemistry of thieno[2,3-d]pyrimidine derivatives and their potential activities against Fms-like tyrosine kinase (FLT3kinase) in addition to their structure-activity relationship studies.