Determination of piroctone olamine (Octopirox) in bulk by UV spectrophotometric method

Abstract

A simple and low-cost UV-spectrophotometric method has been developed and validated for the quantification of Octopirox in bulk. The linearity was found at 307 ± 1 nm in 10-50 µg/ml solution of ethanol-water (1:3, v:v) with r2 = 0.99. The limit of detection was found to be 1.18 μg/ml, while the limit of quantification was 3.58 μg/ml. The method was validated for linearity, accuracy, precision, range, ruggedness and robustness.