Immunoglobulins in Serum and Nasal Secretions Following Infection with Type 1 Parainfluenza Virus and Injection of Inactivated Vaccines

Abstract

The antibody response in serum and nasal secretions was studied in volunteers following infection with type 1 parainfluenza virus and injection with type 1 virus inactivated vaccines. Although both methods of immunization stimulated a serum antibody response, virus infection was more effective in stimulating a local antibody response than was vaccination. Antibody in nasal secretions was found to be associated with γA-immunoglobulins. No significant differences were observed in the immunoglobulin distribution of serum antibody following infection and vaccination.