Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats

Abstract

The mol percentage of 5 hydroxymethylcytosine is 2.2 times greater in the adult than in 2 day old rat brain DNA. The concentration of 5 hydroxymethylcytosine falls in corresponding liver DNA preparations. This normal increase in brain 5 hydroxymethylcytosine is abolished in rats placed on an 8% protein diet 5 days after birth.