ANTIOXIDANT CAPACITY AND ANTIMICROBIAL EFFECTS OF ZINC COMPLEXES OF FLAVONOIDS - DOES SYNERGISM EXIST?

Abstract

There is a constant need for effective drugs, combinations of drugs and methods for the prevention of bacterial and viral infections, including coronavirus. It is known that the role of trace elements in strengthening the human immune system is significant. Vitamins, trace elements, including zinc, iron, selenium, magnesium and copper, and omega-3 fatty acids, play essential physiological roles in promoting the immune system. Zinc is a necessary microelement for basic enzymatic physiological processes; it plays an important role in cell division and is involved in the development of cells responsible for nonspecific immunity. Zinc deficiency is known to predispose patients to viral infection due to reduced antiviral immunity. In addition, flavonoids as plant metabolites play an important role in oxidative stress prevention. This manuscript aims to discuss the roles of zinc, flavonoids and their complexes in vitro, as well as their antioxidant and antimicrobial activities. The justification for the simultaneous use of zinc and flavonoids is also considered.