Solution-Phase Synthesis of an Aminomethyl-Substituted Biaryl Library via Sequential Amine N-Alkylation and Suzuki Cross-Coupling

Michael G. Organ; Elena A. Arvanitis; Craig E. Dixon; David J. Lavorato

Journal Article

Solution-Phase Synthesis of an Aminomethyl-Substituted Biaryl Library via Sequential Amine N-Alkylation and Suzuki Cross-Coupling

Journal of Combinatorial Chemistry (2001) 3(5) 473-476

DOI: 10.1021/cc010018l

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Abstract

Described herein is the semiautomated preparation of a 20-member aminomethyl-substituted biaryl library. The two-step solution-phase synthesis was achieved via sequential N-alkylation of various amines with either 3- or 4-bromobenzyl bromide and Suzuki cross-coupling of the resultant aryl bromides with various boronic acids.

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Organ, M. G., Arvanitis, E. A., Dixon, C. E., & Lavorato, D. J. (2001). Solution-Phase Synthesis of an Aminomethyl-Substituted Biaryl Library via Sequential Amine N-Alkylation and Suzuki Cross-Coupling. Journal of Combinatorial Chemistry, 3(5), 473–476. https://doi.org/10.1021/cc010018l

Solution-Phase Synthesis of an Aminomethyl-Substituted Biaryl Library via Sequential Amine N-Alkylation and Suzuki Cross-Coupling

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