A facile one-pot access to dibenzo[b,e]oxepines by a lewis acid catalysed tandem reaction

Abstract

Dibenzo[b,e]oxepine derivatives have been constructed efficiently by one-pot tandem carbon-carbon bond formation reactions. First, 2-(3,5-dimethoxybenzyloxy)benzaldehydes were treated with various nucleophiles under I2 catalysis and then 1-(3,5-dimethoxybenzyloxy)-3,5- dimethoxybenzene was treated with several aromatic as well as heteroaromatic aldehydes under BF3·Et2O catalytic conditions to provide dibenzo[b,e]oxepines in good yields. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.