Microwave-assisted synthesis of some novel 1,4-dihydropyrimidine derivatives of biological interest

Abstract

Dihydropyrimidines are associated with broad spectrum of biological activities. In view of this 5-benzoyl-6-methyl-4-substituted phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidines were prepared under microwave radiations, and these tetrahydropyrimidines were then converted to S-alkyl-1,4-dihydropyrimidines. Synthesised compounds have been tested for anti-hypertensive activity and have shown some new results about structure-activity relationship.