Pharmacokinetics of modafinil tablets after a single oral dose in Chinese healthy volunteers.

Abstract

The drug and the metabolite (modafinil acid) concns. of plasma sample from the 9 volunteers after taking 100, 200, 300 mg modafinil tablets were detd. by HPLC method, and the pharmacokinetics parameters were calcd. by 3P97 software. The plasma concn.-time curve of modafinil fit two compartment model after oral 100, 200, 300 mg, and the Cmax, AUC0-∞ increased with dose rising. There was no significant difference in pharmacokinetics parameters tmax, t1/2β, Vd, CL between the three groups. The cumulative excretion rate of modafinil in urine in 48 h were (4.44±4.28)%, (3.35±2.20)% and (2.86±1.39)%. The plasma concn.-time curve of modafinil acid fit two compartment model, and the cumulative excretion rate of modafinil acid in urine in 48 h were (33.51±18.90)%, (32.36±19.92)% and (22.88±6.89)%, resp. The plasma concn.-time curve fit two compartment model after an oral dose of modafinil; most of modafinil is transformed to modafinil acid in liver, and the metabolite mainly excreted through kidney. [on SciFinder(R)]