First concise total syntheses of biologically interesting nicolaioidesin C, crinatusin C1, and crinatusin C2

Abstract

The efficient and concise total syntheses of naturally occurring dihydrochalcone nicolaioidesin C, crinatusin C1, and crinatusin C2 have been achieved from the readily available 2,6-dihydroxy-4- methoxyacetophenone and 2,4-dihydroxy-6-methoxyacetophenone. The key steps in the synthetic strategy were aldol reaction and Diels-Alder reaction.