Clinical Characteristics of Side Effects Induced by Administration of Glycyrrhizae Radix and Scutellaria Radix under the Therapy Based on Kampo Diagnosis in Our Hospital

Abstract

Abstract We surveyed side effect incidences with Kampo therapies in 2530 patients based on their Kampo diagnoses. The number of side effects seen, including taste disorder, was 569 in 503 patients. Side effects were noted in 64 (3.0％) of 2139 patients administered Glycyrrhizae radix. The average 63.4±13.8 age of these patients was statistically higher than the overall 54.9±18.1 year mean. Symptoms which led to diagnosis of side effects were high blood pressure in 45 patients, edema in 16 patients, and hypokalemia in only 5 patients. Glycyrrhi- zae radix dose as an extract was 2.0±1.0 (mean±SD) g/day in 34 patients, and as a decoction was 2.2±1.1 g/ day in 29 patients. There was no difference in administration or recovery periods between these two groups. Liver dysfunction was noted in 13 (1.0％) of 1328 patients administered prescriptions containing Scutellaria radix. Scutellaria radix was administered as an extract at 2.3±0.5 g/day in 7 patients, and as a decoction at 2.8 ±0.8 g/day in 6 patients. Although there was no difference in administration periods, the 69.0±52.5 day re- covery period from side effects in the extract group was longer than that of 22.7±16.0 days in the decoction group. Symptom improvement was had for a large portion of these side effects with the first visit, indicating that initial diagnoses were correct. Care should be exercised with regard to inducing side effects, with Kampo medicines, even when using traditional diagnostic standards. Key words : Scutellaria Radix, Glycyrrhizae Radix, liver dysfunction, side effects, pseudoaldosteronism 要旨 患者２５３０例に対する随証漢方治療の副作用を調査した。５０３例に５６９件の味の苦情を含む副作用がみられた。甘草 含有方剤は２１３９例に投与され６４例（３．０％）に副作用を認めた。年齢は６３．４±１３．８歳で全体の５４．９±１８．１歳より高 かった。診断の契機となった症候は，血圧上昇４５例，浮腫１６例であり，低カリウム血症は５例と少なかった。甘草 投与量は，３４例にはエキスで２．０±１．０(Mean±SD)g／日，２９例には煎薬で２．２±１．１g／日であった。両群の投与 期間と回復期間に差はなかった。黄!含有方剤は１３２８例に投与され１３例（１．０％）で肝機能障害を認めた。黄!は７ 例にはエキスで２．３±０．５g／日，６例には煎薬で２．８±０．８g／日が投与されていた。投与期間に有意差はなかった が，回復期間はエキス群６９．０±５２．５日が，煎薬群２２．７±１６．０日より長かった。副作用例の大部分で初診時の症状 の改善は得ており，当初は証に合っていたと思われる。随証治療においても注意する必要がある。 キーワード：黄!，甘草，肝機能障害，副作用，偽アルドステロン症