EFEK PEMBERIAN MADU TRIGONA TERHADAP KADAR ALBUMIN TIKUS PUTIH YANG DIINDUKSI ATORVASTATIN

Abstract

Honey has antioxidant activity that prevents oxidative stress due to high doses of atorvastatin. This study determines the effect of trigona honey provision on albumin levels of white rats given high doses of atorvastatin. Twenty-four white rats (Rattus norvegicus) were divided into 6 groups (n = 4), and each was subjected to different treatment for 5 weeks. One group was given two doses of atorvastatin 20 mg/kg for 3 weeks, followed by 40 mg/kg for 2 weeks. Group 1, normal control, received 0.5% NaCMC, group 2-negative control received atorvastatin, and group 3-honey control received 4.5 ml / kgBB of honey. Groups 4, 5, and 6 each were given Trigona honey at a doses of 1.5 ml / kgBB, 3 ml / kgBB, and 4.5 ml / kgBB, each with atorvastatin. The results showed that the highest albumin level was in the normal control of 2.83 mg/dl, while the lowest was in the negative control of 2.38 mg/dl. Furthermore, groups 3, 4, 5, and 6 had albumin levels of 2.55, 2.53, 2.63, and 2.53 mg/dl, respectively. Statistical analysis showed that there were significant differences (p <0.05) between negative and normal controls. However, there was no significant difference (p> 0.05) between negative controls and three groups of animals given trigona honey with atorvastatin induction. Therefore, the trigona honey did not have a preventive effect on changes in albumin levels in atorvastatin-induced rats.