2′-amino-α-chloroacetophenone as a valuable tool for the synthesis of conveniently-substituted α,β-epoxychalcone derivatives

Abstract

The synthesis of conveniently substituted 2′-amino-α,β- epoxychalcones is described. They were obtained through Darzens condensation of 2′-amino-3′,5′-dimethoxy-O-chloroacetophenone with benzaldehydes. The latter can undergo different cyclization possibilities and afford a variety of flavonoid analogs with biological potential. © 2005 Pharmaceutical Society of Japan.