Molecular mechanisms underlying PGF2α-induced hypertrophy of vascular smooth muscle cells

Abstract

The present review focuses primarily on the studies we made in recent years to improve the understanding of the molecular mechanisms of PGF2α-induced hypertrophy of Vascular Smooth Muscle Cells (VSMC). In this review, we will summarize the recent findings in the context of the PGF2α signaling pathway in three parts: PGF2α binding to its receptor, transactivation of EGF receptor, two independent signaling transduction pathways increasing the expression of NOX1 gene. © 2010 The Pharmaceutical Society of Japan.