High-value biological compounds in jackfruit (Artocarpus heterophyllus Lam.) and their relationship with carcinogenesis

Abstract

Jackfruit contains high-value biological compounds (HVBC) with important biological activity in the inhibition of carcinogenesis, through various mechanisms. This study aimed to identify the HVBC in a methanolic fraction of an extract of jackfruit; which was reported with antimutagenic and antiproliferative activity against PC3 cells (prostate cancer). The profile includes 3 organic acids, 5 phenolic acids, 12 flavonoids, and 2 carotenoids. The identification permitted the establishment of postulates about the possible inhibition mechanisms of the compounds reported with greater biological activity in the different phases of the carcinogenesis process, such as apigenin, artocarpin, cuadraflavone C, moracin C, and β-carotene.