A mixed-ligand zn(Ii)-based coordination polymer for selectively detect 2,4,6-trinitrophenol (TNP) and treatment effect on periodontal diseases via inhibition effect on p. gingivalis growth

Abstract

A new difunctional Zn(II) coordination polymer (CP) with the chemical formula of [Zn(TBTA) (L)1.5 ]n (1) has been synthesized hydrothermally from tetrabromoterephthalic acid (H2 TBTA) and 4,4′-bis(imidazole-1-yl)-biphenyl (L) ligands. Furthermore, due to its strong intense emission and open N donor sites, complex 1 could be used as a light-emitting sensor to determine 2,4,6-trinitrophenol (TNP) which has high selectivity and sensitivity. Furthermore, the anti-bacterial effect of the compound against P. gingivalis in vitro was evaluated by measuring the P. gingivalis growth curves after compound treatment. And the RT-PCR assay was performed to detect the relative expression of ragA and ragB, which are important for the P. gingivalis growth. The potential anti-infectious mechanism was further studied by using molecular docking technique.