Donepezil-induced onset of rheumatoid arthritis: Case report and literature review

Abstract

Donepezil has been approved for treatment of Alzheimer's disease. The common adverse reactions of donepezil in the treatment of Alzheimer's disease include diarrhea and nausea. However, there are also some other rare clinical cases been reported on administration of donepezil, such as mania and delirious behavior. Here, we report a patient with Alzheimer's disease who was induced the onset of rheumatoid arthritis upon treatment with donepezil.