Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan

Abstract

We propose that the preservation of functional integration, estimated from measures of neural synchrony, is a key objective of neurocompensatory mechanisms associated with healthy human ageing. To support this proposal, we demonstrate how phase-locking at the peak alpha frequency in Magnetoencephalography recordings remains invariant over the lifespan in a large cohort of human participants, aged 18-88 years. Using empirically derived connection topologies from diffusion tensor imaging data, we create an in-silico model of whole-brain alpha dynamics. We show that enhancing inter-areal coupling can cancel the effect of increased axonal transmission delays associated with age-related degeneration of white matter tracts, albeit at slower network frequencies. By deriving analytical solutions for simplified connection topologies, we further establish the theoretical principles underlying compensatory network re-organization. Our findings suggest that frequency slowing with age- frequently observed in the alpha band in diverse populations- may be viewed as an epiphenomenon of the underlying compensatory mechanism.