Bacterial coinfections in COVID-19-hospitalized patients

Abstract

OBJECTIVE: The aim of this study was to assess the rate of bacterial infections in COVID-19-hospitalized patients and to analyze the most prevalent germs, sources, risk factors, and its impact on in-hospital mortality. METHODS: This observational retrospective study was conducted on 672 patients hospitalized between April and August 2020 in Nossa Senhora da Conceição Hospital, a public hospital located in Porto Alegre, Brazil. The inclusion criterion was adult patients hospitalized with confirmed COVID-19. Data were collected through chart review. Risk factors for bacterial infection and mortality were analyzed using both univariate and multivariate robust Poisson regression models. RESULTS: Bacterial coinfection was observed in 22.2% of patients. Risk factors for bacterial infections were dementia (RR=2.06 (1.18–3.60); p=0.011), cerebrovascular disease (RR=1.75 (1.15–2.67); p=0.009), active cancer (RR=1.52 (1.082–2.15); p=0.01), need for noninvasive ventilation (RR=2.320 (1.740–3.094); p<0.01), invasive mechanical ventilation (RR=4.63 (2.24–9.56); p<0.01), and renal replacement therapy (RR=1.68 (1.26–2.25); p<0.01). In the adjusted model, bacterial infections were not associated with mortality (0.96 (0.75–1.24); p=0.79). The most common source of infection was due to respiratory, blood, and central venous catheters, with 69 (29.36%), 61 (25.96%), and 59 (25.11%) positive cultures, respectively. CONCLUSION: We observed a high rate of bacterial infections in COVID-19-hospitalized patients, most commonly of respiratory source. Neurologic and oncologic morbidities and need for ventilation and renal replacement therapy was associated with risk factors for bacterial infections. Nevertheless, an association between bacterial infections and hospital mortality was not established.