Preventive effects of soy lecithin in combination with flavonoids on stz induced Diabetes Mellitus in rats

Abstract

The present research work was design to investigate the anti-diabetic effect of Crude Soy lecithin (CSL) in combination with Flavonoids. Various dosed of CSL, quercetin and rutin were standardized and effective dose of CSL, quercetin and rutin was selected. Male Sprague Dawley rats weighing (200-225 g) were subjected to overnight fasting to induced diabetics by STZ (60 mg/kg i.p.) and blood sample was collected after 72 hrs to conform diabetics. Rats with blood glucose level ≥ 200 mg/dl were selected for further study. A dose of combination of CSL and quercetin with rutin p.o. was administered 60 min prior to blood sample withdrawal for estimation of glucose level. Positive control group were treated with STZ injected rats and negative control with metformin (100 mg/kg bw). Effect of CSL in combination with Flavonoids on Blood glucose level, Total Cholesterol level and Total Triglyceride level was evaluated. The results suggested treatment with CSL, quercetin and rutin were significantly decrease plasma glucose, cholesterol and triglyceride level in rats as compared to STZ-Diabetic rats. CSL show anti-diabetic effect alone and in combination with Flavonoids on STZ Induced Diabetes Mellitus (DM) in Rats.