Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2

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Abstract

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To assess the accuracy of routine blood-based laboratory tests to predict mortality and deterioration to severe or critical (from mild or moderate) COVID-19 in people with SARS-CoV-2 infection. Secondary objectives Where data are available, we will investigate whether prognostic accuracy varies according to a specific measurement or test, reference standard, timing of outcome verification, sample type, study design, and setting, including prevalence of the target condition (either by stratified analysis or meta-regression).

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Verbakel, J. Y., De Rop, L., Stegeman, I., Holtman, G. A., Ochodo, E. A., Yang, B., … Leeflang, M. M. G. (2021). Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2. Cochrane Database of Systematic Reviews, 2021(9). https://doi.org/10.1002/14651858.CD015050

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