Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV

Abstract

The development of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) is an efficient strategy for finding new therapeutic agents against human immunodeficiency virus (HIV). A large number of 6-substituted uracil derivatives have been prepared in order to explore new NNRTIs. However, there are few approaches to anti-HIV agents from 1,3-disubstituted uracil derivatives. Therefore, we tried to prepare several 1,3-disubstituted uracils, which were easily obtainable from uracil by preparation under alkali and Mitsunobu conditions, and examined their antiviral activity against HIV-1 and human cytomegalovirus (HCMV). We found that 1-benzyl-3-(3,5-dimethyl-benzyl)uracil and 1-cyanomethyl-3-(3,5-dimethyl-benzyl)-4-thiouracil showed powerful inhibition against HCMV and HIV-1, respectively.